Classic Ayurvedic formulation effects on antidiabetic activity, obesity

During an investigation of the Ayurvedic formulation Chandraprabha vati (CPV) on rats with induced diabetes, Indian researchers determined that the herbal medicine achieved comparable results as metformin – a first-line medication for type-2 diabetes – on reducing hyperglycemia and lipid profile alterations associated with the disease.

The study was undertaken by the National Research Institute for Ayurveda-Siddha Human Resource Development and published in the Journal of Ayurveda and Integrative Medicine.

• A classical Ayurvedic herbal medicine formula, Chandraprabha vati is used to mitigate prameha, a syndrome with many correlations to obesity and diabetes mellitus.
• The investigation involved healthy Wistar rats as test subjects. Alloxan was given to some of these specimens in order to induce hyperglycemia, while otherwise healthy rats were loaded with glucose.
• Various oral doses of pure Chandraprabha vati powder were given to normal, alloxan-hyperglycemic, and glucose-loaded rats. Researchers administered Metformin as a standard drug to another group of rats as a comparison. They assessed the test subjects’ fasting blood sugar, plasma cholesterol, and triglycerides levels during different time intervals.
• According to the oral glucose tolerance test (OGTT), CPV did not markedly affect the blood sugar levels of healthy rats. It did, however, restore the impaired glucose tolerance of glucose-loaded rats. Furthermore, Chandraprabha vati treatment significantly lowered plasma glucose in alloxan-hyperglycemic rats, and it also reduced the levels of cholesterol and triglycerides.
• Finally, CPV and metformin achieved similar anti-hyperglycemic effects. They also made comparable reductions in lipid profile alterations.

Based on the results of their investigations, researchers suggested that further studies should assess the effectiveness of CPV treatment on chronic models of Type 2 diabetes such as Streptozotocin-Nicotinamide-induced diabetes or fructose-induced diabetes.

The full text of the study can be found here.

Journal Reference:

Wanjari MM, Mishra S, Dey YN, Sharma D, Gaidhani SN, Jadhav AD. ANTIDIABETIC ACTIVITY OF CHANDRAPRABHA VATI – A CLASSICAL AYURVEDIC FORMULATION. Journal of Ayurveda and Integrative Medicine. 22 September 2016;7(3):144–150. DOI: 10.1016/j.jaim.2016.08.010.